Insights to Clinical Use of Serial Determination in Titers of Cyclic Citrullinated Peptide Autoantibodies

Kogure, Toshiaki; Tatsumi, Takeshi; Fujinaga, Hiroshi; Niizawa, Atsushi; Terasawa, Katsutoshi

doi:https://doi.org/10.1155/2007/12367

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 012367 | https://doi.org/10.1155/2007/12367

Insights to Clinical Use of Serial Determination in Titers of Cyclic Citrullinated Peptide Autoantibodies

Toshiaki Kogure,¹Takeshi Tatsumi,¹Hiroshi Fujinaga,²Atsushi Niizawa,³and Katsutoshi Terasawa⁴

Received14 Dec 2006

Revised25 Jan 2007

Accepted25 Jan 2007

Published07 Mar 2007

Abstract

Anti-cyclic citrullinated peptide (CCP) antibody is a useful marker for the diagnosis and prognosis of rheumatoid arthritis (RA). Recently, clinical significance of follow-up in anti-CCP antibody titer has been pointed out. Thus, we investigated the serial determination in anti-CCP antibodies titer in RA patients. Six patients with RA, who were followed up for longer than 5 years, were assessed in anti-CCP antibodies and radiographs (Larsen score). Anti-CCP antibodies in frozen sera were measured using ELISA. As a result, 6 patients with RA were divided into two groups: one possessed high titers without variation, and the other was without high titers. Joint damage progressed during observation in 2 out of 3 patients with high anti-CCP titers in a retrospective assessment. In contrast, the RA patient, whose anti-CCP titer decreases although it had been high titer at baseline, did not show increase in the Larsen score. These findings suggest that it might be necessary to analyze changes in anti-CCP to predict the prognosis of joint destruction.

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Copyright

Copyright © 2007 Toshiaki Kogure et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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