Inflammatory Marker but Not Adipokine Predicts Mortality among Long-Term Hemodialysis Patients

Tsai, Yu-Che; Lee, Chien-Te; Huang, Tiao-Lai; Cheng, Ben-Chung; Kuo, Chien-Chun; Su, Yih; Ng, Hwee-Yeong; Yang, Chih-Chau; Chuang, Fong-Rong; Liao, Shang-Chih

doi:https://doi.org/10.1155/2007/19891

Mediators of Inflammation

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Research Article | Open Access

Volume 2007 | Article ID 019891 | https://doi.org/10.1155/2007/19891

Inflammatory Marker but Not Adipokine Predicts Mortality among Long-Term Hemodialysis Patients

Yu-Che Tsai,¹Chien-Te Lee,¹Tiao-Lai Huang,²Ben-Chung Cheng,¹Chien-Chun Kuo,³Yih Su,³Hwee-Yeong Ng,¹Chih-Chau Yang,¹Fong-Rong Chuang,¹and Shang-Chih Liao¹

Received24 Jul 2007

Revised10 Oct 2007

Accepted22 Oct 2007

Published06 Dec 2007

Abstract

Aims: chronic inflammation contributes significantly to the morbidity and mortality of chronic hemodialysis patients. A recent research has shown that adipokines were associated with inflammation in these patients. We aim to investigate whether biomarkers of inflammation, adipokines, and clinical features can predict the outcome of hemodialysis patients. Materials and methods: we enrolled 181 hemodialysis patients (men: 97, mean age: 56.3±13.6) and analyzed predictors of long-term outcomes. Results: during the 3-year followup period, 41 patients died; the main causes of death were infection and cardiovascular disease. Elevated serum levels of hsCRP and albumin and advanced age were highly associated with death (all P<.001). Leptin and adiponectin levels were not significantly different between deceased patients and survivors. Cox-regression analysis indicated that age, diabetes, albumin level, and hsCRP were independent factors predicting mortality. Conclusion: the presence of underlying disease, advanced age, and markers of chronic inflammation is strongly related to survival rate in long-term hemodialysis patients.

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Copyright

Copyright © 2007 Yu-Che Tsai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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