Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2007 (2007), Article ID 31986, 4 pages
http://dx.doi.org/10.1155/2007/31986
Clinical Study

Serum Leptin Levels in Patients with Ocular and Nonocular Behçet's Disease

1Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara 06100, Turkey
2Department of Clinical Biochemistry, Faculty of Medicine, Kırıkkale University, Kırıkkale 71200, Turkey

Received 9 February 2007; Accepted 13 March 2007

Copyright © 2007 F. Nilüfer Yalçındağ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Rizzi, S. Bruno, and R. Dammacco, “Behçet's disease: an immune-mediated vasculitis involving vessels of all sizes,” International Journal of Clinical and Laboratory Research, vol. 27, no. 4, pp. 225–232, 1997. View at Publisher · View at Google Scholar
  2. L. M. Al-Otaibi, S. R. Porter, and T. W. J. Poate, “Behçet's disease: a review,” Journal of Dental Research, vol. 84, no. 3, pp. 209–222, 2005.
  3. J.-L. Mege, N. Dilsen, and V. Sanguedolce et al., “Overproduction of monocyte derived tumor necrosis factor α, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behçet's disease. A comparative study with familial Mediterranean fever and healthy subjects,” Journal of Rheumatology, vol. 20, no. 9, pp. 1544–1549, 1993.
  4. R. S. Ahima and J. S. Flier, “Leptin,” Annual Review of Physiology, vol. 62, pp. 413–437, 2000. View at Publisher · View at Google Scholar · View at PubMed
  5. G. Fantuzzi and R. Faggioni, “Leptin in the regulation of immunity, inflammation, and hematopoiesis,” Journal of Leukocyte Biology, vol. 68, no. 4, pp. 437–446, 2000.
  6. G. Palmer and C. Gabay, “A role for leptin in rheumatic diseases?,” Annals of the Rheumatic Diseases, vol. 62, no. 10, pp. 913–915, 2003. View at Publisher · View at Google Scholar
  7. F. Zhang, M. B. Basinski, and J. M. Beals et al., “Crystal structure of the obese protein leptin-E100,” Nature, vol. 387, no. 6629, pp. 206–209, 1997. View at Publisher · View at Google Scholar · View at PubMed
  8. L. A. Tartaglia, M. Dembski, and X. Weng et al., “Identification and expression cloning of a leptin receptor, OB-R,” Cell, vol. 83, no. 7, pp. 1263–1271, 1995. View at Publisher · View at Google Scholar
  9. P. Maruna, R. Gürlich, R. Fraško, and M. Haluzík, “Serum leptin levels in septic men correlate well with C-reactive protein (CRP) and TNF-alpha but not with BMI,” Physiological Research, vol. 50, no. 6, pp. 589–594, 2001.
  10. H. Baumann, K. K. Morella, and D. W. White et al., “The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 16, pp. 8374–8378, 1996. View at Publisher · View at Google Scholar
  11. B. Wechsler, F. Davatchi, and Y. Mizushima et al., “Criteria for diagnosis of Behçet's disease,” Lancet, vol. 335, no. 8697, pp. 1078–1080, 1990.
  12. J. M. Friedman and J. L. Halaas, “Leptin and the regulation of body weight in mammals,” Nature, vol. 395, no. 6704, pp. 763–770, 1998. View at Publisher · View at Google Scholar · View at PubMed
  13. S. Loffreda, S. Q. Yang, and H. Z. Lin et al., “Leptin regulates proinflammatory immune responses,” FASEB Journal, vol. 12, no. 1, pp. 57–65, 1998.
  14. P. Sarraf, R. C. Frederich, and E. M. Turner et al., “Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia,” Journal of Experimental Medicine, vol. 185, no. 1, pp. 171–175, 1997. View at Publisher · View at Google Scholar
  15. J. E. Janik, B. D. Curti, and R. V. Considine et al., “Interleukin 1α increases serum leptin concentrations in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 9, pp. 3084–3086, 1997. View at Publisher · View at Google Scholar
  16. M. S. Zumbach, M. W. J. Boehme, P. Wahl, W. Stremmel, R. Ziegler, and P. P. Nawroth, “Tumor necrosis factor increases serum leptin levels in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 12, pp. 4080–4082, 1997. View at Publisher · View at Google Scholar
  17. S. R. Bornstein, H. L. Preas, G. P. Chrousos, and A. F. Suffredini, “Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans,” Journal of Infectious Diseases, vol. 178, no. 3, pp. 887–890, 1998.
  18. A. M. Wallace, N. Sattar, and D. C. McMillan, “The co-ordinated cytokine/hormone response to acute injury incorporates leptin,” Cytokine, vol. 12, no. 7, pp. 1042–1045, 2000. View at Publisher · View at Google Scholar · View at PubMed
  19. H.-J. Anders, M. Rihl, A. Heufelder, O. Loch, and M. Schattenkirchner, “Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis,” Metabolism, vol. 48, no. 6, pp. 745–748, 1999. View at Publisher · View at Google Scholar
  20. A. G. Hoppin, L. M. Kaplan, D. Zurakowski, A. M. Leichtner, and A. Bousvaros, “Serum leptin in children and young adults with inflammatory bowel disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 26, no. 5, pp. 500–505, 1998. View at Publisher · View at Google Scholar
  21. B. Turan, H. Gallati, H. Erdi, A. Gürler, B. A. Michel, and P. M. Villiger, “Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Behçet's disease; soluble TNFR-75 as a biological marker of disease activity,” Journal of Rheumatology, vol. 24, no. 1, pp. 128–132, 1997.
  22. C. Evereklioglu, H. S. Inalöz, and N. Kirtak et al., “Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity,” British Journal of Dermatology, vol. 147, no. 2, pp. 331–336, 2002. View at Publisher · View at Google Scholar
  23. S. Kavuncu, F. Koç, and M. Kurt et al., “Evaluation of serum leptin concentration in Behçet's disease with ocular involvement,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 243, no. 11, pp. 1158–1160, 2005. View at Publisher · View at Google Scholar · View at PubMed