The Levels of Ghrelin, TNF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math>, and IL-6 in Children with Cyanotic and Acyanotic Congenital Heart Disease

Yilmaz, Erdal; Ustundag, Bilal; Sen, Yasar; Akarsu, Saadet; Kurt, A. Nese Citak; Dogan, Yasar

doi:https://doi.org/10.1155/2007/32403

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 032403 | https://doi.org/10.1155/2007/32403

The Levels of Ghrelin, TNF-α, and IL-6 in Children with Cyanotic and Acyanotic Congenital Heart Disease

Erdal Yilmaz,¹Bilal Ustundag,²Yasar Sen,³Saadet Akarsu,⁴A. Nese Citak Kurt,⁴and Yasar Dogan⁴

Received16 Mar 2007

Accepted06 Jul 2007

Published30 Aug 2007

Abstract

Background/Aim. Ghrelin has effects on nutrient intake and growth. The cause of growth retardation in congenital heart disease is multifactorial. The aim of the present study is to investigate the ghrelin in congenital heart disease and the association of ghrelin with TNF-α and IL-6. Materials and methods. We measured serum ghrelin, TNF-α, and IL-6 levels using spesific immunoassay in 68 patients (47 acyanotic, 21 cyanotic with congenital heart disease) and in 25 control subjects. Results. In comparison to controls, serum ghrelin, TNF-α levels were significantly higher in acyanotic patients and cyanotic patients with congenital heart disease (P<.0001). In acyanotic and cyanotic patients with congenital heart disease, there was a positive correlation between ghrelin and TNF-α (r=.485, P<.05 and r=.573 , P<.01, resp.). Conclusion. Serum ghrelin levels is elevated in acyanotic and cyanotic patients with congenital heart disease. Increased ghrelin levels represents malnutrition and growth retardation in these patients. The relation of ghrelin with cytokines may be explained by the possible effect of chronic congestive heart failure and chronic shunt hypoxemia.

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Copyright © 2007 Erdal Yilmaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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