Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain

Chen, Qianming; Xia, Juan; Lin, Mei; Zhou, Hongmei; Li, Bingqi

doi:https://doi.org/10.1155/2007/45327

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 045327 | https://doi.org/10.1155/2007/45327

Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain

Qianming Chen,¹Juan Xia,²Mei Lin,¹Hongmei Zhou,¹and Bingqi Li¹

Received19 Jan 2007

Accepted26 Feb 2007

Published22 Apr 2007

Abstract

Objective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. Methods. 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitiate depressive status and pain levels of subjects, respectively. Results. 15 (31%) patients displayed substantial depressive symptoms (HRSD ≧16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P=.002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P=.011). However, no significant relations were found between interleukin-6 and HRSD scores (P=.317). Conclusions. Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as precipitating factors in BMS etiopathogenesis.

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Copyright © 2007 Qianming Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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