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Mediators of Inflammation
Volume 2007, Article ID 45327, 4 pages
Clinical Study

Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain

1Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China
2Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, China

Received 19 January 2007; Accepted 26 February 2007

Copyright © 2007 Qianming Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. Methods. 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitiate depressive status and pain levels of subjects, respectively. Results. 15 (31%) patients displayed substantial depressive symptoms (HRSD 16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P=.002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P=.011). However, no significant relations were found between interleukin-6 and HRSD scores (P=.317). Conclusions. Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as precipitating factors in BMS etiopathogenesis.