Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease

Borges Jr., Ivan; Moreira, Emília Addison Machado; Filho, Danilo Wilhem; de Oliveira, Tiago Bittencourt; da Silva, Marcelo Barreto Spirelle; Fröde, Tânia Silvia

doi:https://doi.org/10.1155/2007/45794

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 045794 | https://doi.org/10.1155/2007/45794

Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease

Ivan Borges Jr.,¹Emília Addison Machado Moreira,¹Danilo Wilhem Filho,²Tiago Bittencourt de Oliveira,²Marcelo Barreto Spirelle da Silva,³and Tânia Silvia Fröde³

Received31 Jan 2007

Revised23 May 2007

Accepted25 May 2007

Published30 Aug 2007

Abstract

Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis. Subject and methods. Eighteen subjects were divided in two groups: experimental (age 52.9±5.0) and control (age 51.1±9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student t test and P<.05. Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05). Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.

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Copyright © 2007 Ivan Borges Jr. et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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