Perinatal Changes of Cardiac Troponin-I in Normal and  Intrauterine Growth-Restricted Pregnancies

Iacovidou, Nicoletta; Boutsikou, Maria; Gourgiotis, Demetrios; Briana, Despina D.; Baka, Stavroula; Vraila, Venetia-Maria; Kontara, Louiza; Hassiakos, Demetrios; Malamitsi-Puchner, Ariadne

doi:https://doi.org/10.1155/2007/53921

Mediators of Inflammation

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Research Article | Open Access

Volume 2007 | Article ID 053921 | https://doi.org/10.1155/2007/53921

Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies

Nicoletta Iacovidou,¹Maria Boutsikou,¹Demetrios Gourgiotis,²Despina D. Briana,¹Stavroula Baka,¹Venetia-Maria Vraila,²Louiza Kontara,¹Demetrios Hassiakos,¹and Ariadne Malamitsi-Puchner¹

Received21 Apr 2007

Accepted21 May 2007

Published26 Jun 2007

Abstract

Intrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI), a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to delivery, the doubly clamped umbilical cords (representing fetal state), and their 20 IUGR and 20 appropriate-for-gestational-age (AGA) neonates on day 1 and 4 postpartum. At all time points, no differences in cTnI levels were observed between the AGA and IUGR groups. Strong positive correlations were documented between maternal and fetal/neonatal values (r≥.498, P≤.025 in all cases in the AGA and r≥.615, P≤.009 in all cases in the IUGR group). These results may indicate (a) normal heart function, due to heart sparing, in the IUGR group (b) potential crossing of the placental barrier by cTnI in both groups

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Copyright © 2007 Nicoletta Iacovidou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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