Mediators of Inflammation
Volume 2007 (2007), Article ID 72356, 6 pages
http://dx.doi.org/10.1155/2007/72356
Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery
1Institute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech Republic
2Department of Cardiac Surgery, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech Republic
Received 10 July 2007; Accepted 4 September 2007
Copyright © 2007 Manuela Kudlova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives. The changes in the serum levels of lipopolysaccharide binding protein
(LBP) and sCD14 during cardiac surgery were followed in this study.
Design. Thirty-four patients, 17 in each group, were randomly assigned to coronary artery
bypass grafting surgery
performed either with (“on-pump”) or without (“off-pump”) cardiopulmonary
bypass. LBP and sCD14 were evaluated
by ELISA. Results. The serum levels of LBP were gradually increased from the 1st
postoperative day and reached their
maximum on the 3rd postoperative day in both “on-pump” and
“off-pump” patients (