The Immunohistochemistry Profile of Lymphocytic Gastritis in Celiac Disease and Helicobacter Pylori Infection: Interplay between Infection and Inflammation

Broide, Efrat; Sandbank, Judith; Scapa, Eitan; Kimchi, Nimrod Alain; Shapiro, Michael; Lerner, Aaron

doi:https://doi.org/10.1155/2007/81838

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 081838 | https://doi.org/10.1155/2007/81838

The Immunohistochemistry Profile of Lymphocytic Gastritis in Celiac Disease and Helicobacter Pylori Infection: Interplay between Infection and Inflammation

Efrat Broide,¹Judith Sandbank,²Eitan Scapa,¹Nimrod Alain Kimchi,¹Michael Shapiro,¹and Aaron Lerner³

Received10 Jul 2007

Accepted24 Sept 2007

Published15 Nov 2007

Abstract

Lymphocytic gastritis (LG) is associated with helicobacter pylori (Hp) and celiac disease (CD). We aimed to clarify the relationship between Hp infection and CD by defining a unique histopathology profile of LG in these two diseases. Forty patients who underwent upper endoscopy were divided into four groups: eight controls, ten active CD patients without Hp, twelve CD negative with Hp, and ten active CD with Hp infection. Antral samples were assessed by immunohistochemical staining for CD20, CD3, CD4, CD8, CD57, CNA42, and Ki67 for lymphoid aggregates, intraepithelial lymphocytes (IELs) number, density of lamina propria (LP) lymphocytes, and inflammatory glandular involvement. Only IELs positive for CD3 and CD8 were increased significantly in CD patients with or without Hp infection. Hp did not contribute to the number of CD8 IELs. In complicated cases with Hp and suspicious for CD, the number of CD8+ IELs hints toward a CD rather than Hp infection.

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Copyright © 2007 Efrat Broide et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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