Mediators of Inflammation
Volume 2007 (2007), Article ID 93148, 9 pages
http://dx.doi.org/10.1155/2007/93148
Inhibitory Effect of Inflexinol on Nitric Oxide Generation and iNOS Expression via Inhibition of NF-κ B Activation
1College of Pharmacy and CBITRC, Chungbuk National University 12, Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, South Korea
2National Institute of Environmental Research, Kyungseo-dong, Seo-gu, Incheon 404-780, South Korea
3Department of Medical Beauty, Konyang University, 26 Nae-dong, Nonsan, Chungnam 320-711, South Korea
Received 6 October 2006; Accepted 24 January 2007
Copyright © 2007 Jae Woong Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Inflexinol, an ent-kaurane diterpenoid, was isolated from the
leaves of Isodon excisus. Many diterpenoids isolated from the genus
Isodon (Labiatae) have antitumor and
antiinflammatory activities. We investigated the antiinflammatory effect of inflexinol in
RAW 264.7 cells and astrocytes. As a result, we found that inflexinol
(1, 5, 10