Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2007, Article ID 93726, 6 pages
http://dx.doi.org/10.1155/2007/93726
Clinical Study

Increased Endothelin-1 Levels of BAL Fluid in Patients with Behçet's Disease

1Homeostasis and Cell Dysfunction Unit Research 99/UR/08-40, Medicine University of Tunis, Tunis 1007, Tunisia
2Pneumology Hospital A. Mami, Department of Paediatric and Respiratory Diseases, Pavillon B, Ariana 2080, Tunisia

Received 24 November 2006; Revised 13 January 2007; Accepted 16 January 2007

Copyright © 2007 Kamel Hamzaoui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Yazici, S. Yurdakul, V. Hamuryudan, and I. Fresko, “Behçet's syndrome,” in Rheumatology, M. C. Hochberg, J. A. Silman, J. S. Smolen, M. E. Weinblatt, and M. H. Weisman, Eds., pp. 1665–1669, Mosby, London, UK, 3rd edition, 2003. View at Google Scholar
  2. D. Erkan, Y. Yazici, A. Sanders, D. Trost, and H. Yazici, “Is Hughes-Stovin syndrome Behçet's disease?” Clinical and Experimental Rheumatology, vol. 22, no. 4, supplement 24, pp. S64–S68, 2004. View at Google Scholar
  3. A. Hamzaoui and K. Hamzaoui, “Pulmonary complications of Behçet's disease and Takayasu's arteritis,” Revue des Maladies Respiratoires, vol. 22, no. 6, part 1, pp. 999–1019, 2005. View at Publisher · View at Google Scholar
  4. K. Aksu, H. Koçanaogullari, G. Keser et al., “A case of Behçet's disease with pulmonary arterial aneurysm and secondary amyloidosis,” Rheumatology, vol. 41, no. 7, pp. 831–832, 2002. View at Publisher · View at Google Scholar
  5. K. Terashita, S. Kato, M. Sata, S. Inoue, H. Nakamura, and H. Tomoike, “Increased endothelin-1 levels of BAL fluid in patients with pulmonary sarcoidosis,” Respirology, vol. 11, no. 2, pp. 145–151, 2006. View at Publisher · View at Google Scholar
  6. C. Odoux, B. Crestani, G. Lebrun et al., “Endothelin-1 secretion by alveolar macrophages in systemic sclerosis,” American Journal of Respiratory and Critical Care Medicine, vol. 156, no. 5, pp. 1429–1435, 1997. View at Google Scholar
  7. M. Kayikçioglu, K. Aksu, C. Hasdemir et al., “Endothelial functions in Behçet's disease,” Rheumatology International, vol. 26, no. 4, pp. 304–308, 2006. View at Publisher · View at Google Scholar
  8. A. Gül, “Behçet's disease: an update on the pathogenesis,” Clinical and Experimental Rheumatology, vol. 19, no. 5, supplement 24, pp. S6–S12, 2001. View at Google Scholar
  9. J. C. Chambers, D. O. Haskard, and J. S. Kooner, “Vascular endothelial function and oxidative stress mechanisms in patients with Behçet's syndrome,” Journal of the American College of Cardiology, vol. 37, no. 2, pp. 517–520, 2001. View at Publisher · View at Google Scholar
  10. R. Joannides, W. E. Haefeli, L. Linder et al., “Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo,” Circulation, vol. 91, no. 5, pp. 1314–1319, 1995. View at Google Scholar
  11. A. Örem, Y. E. Yandi, B. Vanizor, G. Çimşit, H. A. Uydu, and M. Malkoç, “The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behçet's disease,” Clinical Biochemistry, vol. 35, no. 3, pp. 217–224, 2002. View at Publisher · View at Google Scholar
  12. A. J. Peacock, K. E. Dawes, A. Shock, A. J. Gray, J. T. Reeves, and G. J. Laurent, “Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts,” American Journal of Respiratory Cell and Molecular Biology, vol. 7, no. 5, pp. 492–499, 1992. View at Google Scholar
  13. C. L. Golden, J. P. Kohler, H. S. Nick, and G. A. Visner, “Effects of vasoactive and inflammatory mediators on endothelin-1 expression in pulmonary endothelial cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 12, no. 5, pp. 503–512, 1995. View at Google Scholar
  14. L. Guembe and A. C. Villaro, “Immunohistochemical mapping of endothelin in the developing and adult mouse lung,” Journal of Histochemistry and Cytochemistry, vol. 49, no. 10, pp. 1301–1309, 2001. View at Google Scholar
  15. B. Hocher, A. Schwarz, K. A. Fagan et al., “Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice,” American Journal of Respiratory Cell and Molecular Biology, vol. 23, no. 1, pp. 19–26, 2000. View at Google Scholar
  16. M. Marini, S. Carpi, A. Bellini, F. Patalano, and S. Mattoli, “Endothelin-1 induces increased fibronectin expression in human bronchial epithelial cells,” Biochemical and Biophysical Research Communications, vol. 220, no. 3, pp. 896–899, 1996. View at Publisher · View at Google Scholar
  17. B. Wechsler, F. Davatchi, Y. Mizushima et al., “Criteria for diagnosis of Behçet's disease,” Lancet, vol. 335, no. 8697, pp. 1078–1080, 1990. View at Google Scholar
  18. A. Hamzaoui, H. Ghraïri, J. Ammar, S. Zekri, F. Guemira, and K. Hamzaoui, “IL-18 mRNA expression and IFN-γ induction in bronchoalveolar lavage from Behçet's disease,” Clinical and Experimental Rheumatology, vol. 21, no. 4, supplement 30, pp. S8–S14, 2003. View at Google Scholar
  19. M. Kraft, W. R. Beam, S. E. Wenzel, M. R. Zamora, R. F. O'Brien, and R. J. Martin, “Blood and bronchoalveolar lavage endothelin-1 levels in nocturnal asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 4, pp. 946–952, 1994. View at Google Scholar
  20. F. Erkan, “Pulmonary involvement in Behçet disease,” Current Opinion in Pulmonary Medicine, vol. 5, no. 5, pp. 314–318, 1999. View at Publisher · View at Google Scholar
  21. V. Hamuryudan, T. Er, E. Seyahi et al., “Pulmonary artery aneurysms in Behçet syndrome,” The American Journal of Medicine, vol. 117, no. 11, pp. 867–870, 2004. View at Publisher · View at Google Scholar
  22. U. Schmitz-Huebner and J. Knop, “Evidence for an endothelial cell dysfunction in association with Behçet's disease,” Thrombosis Research, vol. 34, no. 4, pp. 277–285, 1984. View at Publisher · View at Google Scholar
  23. A. Giaid, R. P. Michel, D. J. Stewart, M. Sheppard, B. Corrin, and Q. Hamid, “Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis,” Lancet, vol. 341, no. 8860, pp. 1550–1554, 1993. View at Publisher · View at Google Scholar
  24. H. Houman, A. Hamzaoui, I. B. Ghorbal, M. S. Khanfir, M. Feki, and K. Hamzaoui, “Tc1/Tc2 ratio in the inflammatory process in patients with Behçet's disease,” Mediators of Inflammation, vol. 13, no. 4, pp. 247–253, 2004. View at Publisher · View at Google Scholar
  25. S. Kaneko, N. Suzuki, N. Yamashita et al., “Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behçet's disease (BD) in Japan,” Clinical and Experimental Immunology, vol. 108, no. 2, pp. 204–212, 1997. View at Publisher · View at Google Scholar
  26. H. Direskeneli, E. Eksioglu-Demiralp, S. Yavuz et al., “T cell responses to 60/65 kDa heat shock protein derived peptides in Turkish patients with Behçet's disease,” Journal of Rheumatology, vol. 27, no. 3, pp. 708–713, 2000. View at Google Scholar
  27. W.-U. Kim, J.-H. Do, K.-S. Park et al., “Enhanced production of macrophage inhibitory protein-1a in patients with Behçet's disease,” Scandinavian Journal of Rheumatology, vol. 34, no. 2, pp. 129–135, 2005. View at Publisher · View at Google Scholar
  28. S. Molet, K. Furukawa, A. Maghazechi, Q. Hamid, and A. Giaid, “Chemokine- and cytokine-induced expression of endothelin 1 and endothelin-converting enzyme 1 in endothelial cells,” Journal of Allergy and Clinical Immunology, vol. 105, no. 2, pp. 333–338, 2000. View at Publisher · View at Google Scholar
  29. M. S. Kurokawa and N. Suzuki, “Behçet's disease,” Clinical and Experimental Medicine, vol. 4, no. 1, pp. 10–20, 2004. View at Publisher · View at Google Scholar
  30. G. W. Chalmers, K. J. Macleod, S. Sriram et al., “Sputum endothelin-1 is increased in cystic fibrosis and chronic obstructive pulmonary disease,” European Respiratory Journal, vol. 13, no. 6, pp. 1288–1292, 1999. View at Publisher · View at Google Scholar
  31. M. O. Oztas, M. Onder, M. A. Gurer, N. Bukan, and B. Sancak, “Serum interleukin 18 and tumour necrosis factor-α levels are increased in Behçet's disease,” Clinical and Experimental Dermatology, vol. 30, no. 1, pp. 61–63, 2005. View at Publisher · View at Google Scholar
  32. E. Bozoglu, A. Dinc, H. Erdem, S. Pay, I. Simsek, and I. H. Kocar, “Vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behçet's patients with venous thrombosis,” Clinical and Experimental Rheumatology, vol. 23, no. 4, supplement 38, pp. S42–S48, 2005. View at Google Scholar
  33. F. Finsnes, T. Lyberg, G. Christensen, and O. H. Skjønsberg, “Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation,” American Journal of Physiology. Lung Cellular and Molecular Physiology, vol. 280, no. 4, pp. L659–L665, 2001. View at Google Scholar
  34. M. M. Cerinic and M. B. Kahaleh, “Beauty and the beast. The nitric oxide paradox in systemic sclerosis,” Rheumatology, vol. 41, no. 8, pp. 843–847, 2002. View at Publisher · View at Google Scholar
  35. J. A. Karasneh, A. H. Hajeer, A. Silman, J. Worthington, W. E. R. Ollier, and A. Gul, “Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behçet's disease,” Rheumatology, vol. 44, no. 5, pp. 614–617, 2005. View at Publisher · View at Google Scholar
  36. J. U. Kim, H. K. Chang, S. S. Lee et al., “Endothelial nitric oxide synthase gene polymorphisms in Behçet's disease and rheumatic diseases with vasculitis,” Annals of the Rheumatic Diseases, vol. 62, no. 11, pp. 1083–1087, 2003. View at Publisher · View at Google Scholar
  37. F. Oksel, G. Keser, M. Ozmen et al., “Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with Behçet's disease,” Clinical and Experimental Rheumatology, vol. 24, no. 5, supplement 42, pp. S79–S82, 2006. View at Google Scholar
  38. M. Cukiernik, D. Hileeto, T. Evans, S. Mukherjee, D. Downey, and S. Chakrabarti, “Vascular endothelial growth factor in diabetes induced early retinal abnormalities,” Diabetes Research and Clinical Practice, vol. 65, no. 3, pp. 197–208, 2004. View at Publisher · View at Google Scholar