Inhibition of Angiogenic Factor Production from Murine Mast Cells by an Antiallergic Agent (Epinastine Hydrochloride) In Vitro
Figure 3
Suppressive activity of epinastine hydrochrolide (EP) on mRNA expression for angiogenic
factors in mast cells in IgE-mediated mechanism. Murine peritoneal mast cells
( cells/mL) sensitized with IgE specific for ovalbumin (OVA)
were stimulated with 10 ng/mL OVA for 4 hours. mRNA expression for
angiogenic factors was examined by
real-time RT-PCR. The data are expressed as the mean ± SE of triplicate
cultures. KC: keratinocyte-derived chemokine (a); TNF: TNF-α (b);
VEGF: vascular endothelial growth factor (c); * versus control (EP at 0 ng/mL).