Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors

Table 2

Distribution of frequencies of IL-18 gene promoter genotypes at the −137 G→C position in relation to the level of LPS-stimulated IL-18 secretion.

Quantiles of level of LPS-	IL-18 level	−137GG	−137CN	(pemf)	p𝜒^2
stimulated IL-18 secretion	pg/mL	n	n
Low (0–15%)	0–25.6	3	14	0.0098	<0.05
Medium (15–85%)	25.7–114.2	48	50
High (85–100%)	114.3–298.4	14	14	0.1445	>0.1
All		65	78