The NF-B Inhibitor Curcumin Blocks Sepsis-Induced Muscle Proteolysis
Figure 1
Curcumin inhibits sepsis-induced muscle proteolysis. (a) Rats were treated with different doses of curcumin and the inhibition of muscle protein breakdown in septic rats was calculated as percent inhibition of tyrosine release from muscles of curcumin-treated septic rats compared with tyrosine release from muscles of vehicle-treated septic rats. Results are from experiments in which 8 septic rats treated with vehicle and 8 septic rats treated with curcumin were studied for each total dose of curcumin
indicated in the figure. (b) Sham-operated and septic rats were treated with vehicle (control) or curcumin (total dose 1800 mg/kg divided into three equal doses administered intraperitoneally 1 hour before and 8 and 15 hours after sham-operation or CLP). Protein breakdown rates were determined in incubated extensor digitorum longus muscles 16 hours after sham-operation or CLP by measuring net release of tyrosine. Results are means ±SEM with in each group. * versus all other groups by ANOVA.
