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Mediators of Inflammation
Volume 2008, Article ID 469439, 7 pages
Research Article

Six Years Follow-up of the Levels of TNF- and IL-6 in Patients with Complex Regional Pain Syndrome Type 1

1Department of Anesthesiology, Pain Treatment Center, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
2Department of Anesthesiology, Experimental Anesthesiology, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands

Received 11 February 2008; Accepted 6 May 2008

Academic Editor: Jan van Amsterdam

Copyright © 2008 Feikje Wesseldijk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In an earlier study, levels of the proinflammatory cytokines TNF- and IL-6 are higher in blisters fluid from the complex regional pain syndrome type 1 (CRPS1) side obtained at 6 and 30 months (median) after the initial event. The aim of this follow-up study is to determine the involvement of these cytokines in long lasting CRPS1. Twelve CRPS1 patients, with median disease duration of 72 months, participated. The levels of TNF- and IL-6 were measured in blister fluid; disease activity was reevaluated by measuring pain and differences in temperature, volume, and mobility between both extremities. Differences in levels of IL-6 and TNF- and mobility between both sides were significantly decreased. Pain and differences in temperature and volume were not significantly altered. No correlation was found between the cytokines and the disease characteristics. These results indicate that IL-6 and TNF- are only partially responsible for the signs and symptoms of CRPS1.