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Mediators of Inflammation
Volume 2008, Article ID 737141, 7 pages
http://dx.doi.org/10.1155/2008/737141
Clinical Study

Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor- , and Interleukin-1 Levels in Neonatal Late-Onset Sepsis

Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, Turkey

Received 25 March 2008; Revised 14 August 2008; Accepted 25 August 2008

Academic Editor: Ariadne Malamitsi-Puchner

Copyright © 2008 Birsen Ucar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. S. Lam and P. C. Ng, “Biochemical markers of neonatal sepsis,” Pathology, vol. 40, no. 2, pp. 141–148, 2008. View at Publisher · View at Google Scholar
  2. N. M. Fida, J. A. Al-Mughales, and M. F. Fadellah, “Serum concentrations of interleukin-1 alpha, interleukin-6 and tumor necrosis factor-alpha in neonatal sepsis and meningitis,” Saudi Medical Journal, vol. 27, no. 10, pp. 1508–1514, 2006. View at Google Scholar
  3. W. M. Fendler and A. J. Piotrowski, “Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates,” Journal of Paediatrics and Child Health, vol. 44, no. 3, pp. 114–118, 2008. View at Publisher · View at Google Scholar
  4. S. Arnon, I. Litmanovitz, R. H. Regev, S. Bauer, R. Shainkin-Kestenbaum, and T. Dolfin, “Serum amyloid A: an early and accurate marker of neonatal early-onset sepsis,” Journal of Perinatology, vol. 27, no. 5, pp. 297–302, 2007. View at Publisher · View at Google Scholar
  5. S. Arnon, I. Litmanovitz, R. Regev et al., “Serum amyloid A protein is a useful inflammatory marker during late-onset sepsis in preterm infants,” Biology of the Neonate, vol. 87, no. 2, pp. 105–110, 2005. View at Google Scholar
  6. A. Enguix, C. Rey, A. Concha, A. Medina, D. Coto, and M. A. Diéguez, “Comparison of procalcitonin with C-reactive protein and serum amyloid for the early diagnosis of bacterial sepsis in critically ill neonates and children,” Intensive Care Medicine, vol. 27, no. 1, pp. 211–215, 2001. View at Google Scholar
  7. M. M. Levy, M. P. Fink, J. C. Marshall et al., “2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference,” Critical Care Medicine, vol. 31, no. 4, pp. 1250–1256, 2003. View at Publisher · View at Google Scholar
  8. U. Töllner, “Early diagnosis of septicemia in the newborn. Clinical studies and sepsis score,” European Journal of Pediatrics, vol. 138, no. 4, pp. 331–337, 1982. View at Publisher · View at Google Scholar
  9. C. Pizzini, M. Mussap, M. Plebani, and V. Fanos, “C-reactive protein and serum amyloid A protein in neonatal infections,” Scandinavian Journal of Infectious Diseases, vol. 32, no. 3, pp. 229–235, 2000. View at Publisher · View at Google Scholar
  10. S. Arnon, I. Litmanovitz, R. Regev, M. Lis, R. Shainkin-Kestenbaum, and T. Dolfin, “Serum amyloid A protein in the early detection of late-onset bacterial sepsis in preterm infants,” Journal of Perinatal Medicine, vol. 30, no. 4, pp. 329–332, 2002. View at Publisher · View at Google Scholar
  11. L. E. Jensen and A. S. Whitehead, “Regulation of serum amyloid A protein expression during the acute-phase response,” Biochemical Journal, vol. 334, part 3, pp. 489–503, 1998. View at Google Scholar
  12. C. Gabay, B. Genin, G. Mentha, P. B. Iynedjian, P. Roux-Lombard, and P. A. Guerne, “IL-1 receptor antagonist (IL-1Ra) does not inhibit the production of C-reactive protein or serum amyloid A protein by human primary hepatocytes. Differential regulation in normal and tumour cells,” Clinical and Experimental Immunology, vol. 100, no. 2, pp. 306–313, 1995. View at Google Scholar
  13. H. Døllner, L. Vatten, and R. Austgulen, “Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules,” Journal of Clinical Epidemiology, vol. 54, no. 12, pp. 1251–1257, 2001. View at Publisher · View at Google Scholar
  14. R. C. Couto, J. A. A. Barbosa, T. M. G. Pedrosa, and F. M. Biscione, “C-reactive protein-guided approach may shorten length of antimicrobial treatment of culture-proven late-onset sepsis. An intervention study,” Brazilian Journal of Infectious Diseases, vol. 11, no. 2, pp. 240–245, 2007. View at Publisher · View at Google Scholar
  15. P. Nuntnarumit, O. Pinkaew, and S. Kitiwanwanich, “Predictive values of serial C-reactive protein in neonatal sepsis,” Journal of the Medical Association of Thailand, vol. 85, supplement 4, pp. S1151–S1158, 2002. View at Google Scholar
  16. D. Içağasioğlu, H. Caksen, I. Sütçu, and O. Cevit, “Serum C-reactive protein and interleukin6 levels in neonatal sepsis,” Acta Medica, vol. 45, no. 3, pp. 111–113, 2002. View at Google Scholar
  17. R. C. Silveira and R. S. Procianoy, “Evaluation of interleukin-6, tumour necrosis factor-α and interleukin- 1β for early diagnosis of neonatal sepsis,” Acta Paediatrica, vol. 88, no. 6, pp. 647–650, 1999. View at Publisher · View at Google Scholar
  18. A. Atici, M. Satar, and N. Alparslan, “Serum interleukin-1β in neonatal sepsis,” Acta Paediatrica, vol. 85, no. 3, pp. 371–374, 1996. View at Publisher · View at Google Scholar
  19. P. C. Ng, S. H. Cheng, K. M. Chui et al., “Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 77, no. 3, pp. F221–F227, 1997. View at Google Scholar
  20. R. Schindler, J. Mancilla, S. Endres, R. Ghorbani, S. C. Clark, and C. A. Dinarello, “Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF,” Blood, vol. 75, no. 1, pp. 40–47, 1990. View at Google Scholar
  21. E. T. Rietschel, H. Brade, O. Holst et al., “Bacterial endotoxin: chemical constitution, biological recognition, host response, and immunological detoxification,” Current Topics in Microbiology and Immunology, vol. 216, pp. 39–81, 1996. View at Google Scholar
  22. R. Berner, C. M. Niemeyer, J. U. Leititis et al., “Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-a, interleukin (IL)-1ß, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis,” Pediatric Research, vol. 44, no. 4, pp. 469–477, 1998. View at Publisher · View at Google Scholar
  23. A. Atici, M. Satar, S. Cetíner, and A. Yaman, “Serum tumor necrosis factor-alpha in neonatal sepsis,” American Journal of Perinatology, vol. 14, no. 7, pp. 401–404, 1997. View at Google Scholar
  24. C. Santana Reyes, F. García-Muñoz, D. Reyes, G. González, C. Dominguez, and E. Domenech, “Role of cytokines (interleukin-1β, 6, 8, tumour necrosis factor-α, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis,” Acta Paediatrica, vol. 92, no. 2, pp. 221–227, 2003. View at Google Scholar
  25. I. R. Makhoul, A. Yacoub, T. Smolkin, P. Sujov, I. Kassis, and H. Sprecher, “Values of C-reactive protein, procalcitonin, and Staphylococcus-specific PCR in neonatal late-onset sepsis,” Acta Paediatrica, vol. 95, no. 10, pp. 1218–1223, 2006. View at Publisher · View at Google Scholar
  26. D. Turner, C. Hammerman, B. Rudensky, Y. Schlesinger, and M. S. Schimmel, “The role of procalcitonin as a predictor of nosocomial sepsis in preterm infants,” Acta Paediatrica, vol. 95, no. 12, pp. 1571–1576, 2006. View at Publisher · View at Google Scholar
  27. C. Chiesa, G. Pellegrini, A. Panero et al., “C-reactive protein, interleukin-6, and procalcitonin in the immediate postnatal period: influence of illness severity, risk status, antenatal and perinatal complications, and infection,” Clinical Chemistry, vol. 49, no. 1, pp. 60–68, 2003. View at Publisher · View at Google Scholar
  28. J. Blommendahl, M. Janas, S. Laine, A. Miettinen, and P. Ashorn, “Comparison of procalcitonin with CRP and differential white blood cell count for diagnosis of culture-proven neonatal sepsis,” Scandinavian Journal of Infectious Diseases, vol. 34, no. 8, pp. 620–622, 2002. View at Google Scholar
  29. A. R. Franz, M. Kron, F. Pohlandt, and G. Steinbach, “Comparison of procalcitonin with interleukin 8, C-reactive protein and differential white blood cell count for the early diagnosis of bacterial infections in newborn infants,” The Pediatric Infectious Disease Journal, vol. 18, no. 8, pp. 666–671, 1999. View at Publisher · View at Google Scholar
  30. H. Caksen, S. Kurtoglu, I. K. Hallaç, H. B. Ustünbas, K. Uzüm, and H. Kiliç, “The relationship between scoring systems and cytokine levels in neonatal sepsis,” Annals of the Academy of Medicine Singapore, vol. 32, no. 3, pp. 418–420, 2003. View at Google Scholar