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Mediators of Inflammation
Volume 2008 (2008), Article ID 781425, 11 pages
http://dx.doi.org/10.1155/2008/781425
Research Article

Effects of Radix Adenophorae and Cyclosporine A on an OVA-Induced Murine Model of Asthma by Suppressing to T Cells Activity, Eosinophilia, and Bronchial Hyperresponsiveness

1Laboratory of Herbology, College of Oriental Medicine, Daegu Hanny University, Daegu 706060, South Korea
2Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 300716, South Korea
3Laboratory of Herbology, College of Oriental Medicine, Sangji University, Wonju 220702, South Korea
4Laboratory of Herbology, College of Oriental Medicine, Daejeon University, Daejeon 300716, South Korea

Received 22 October 2007; Accepted 2 January 2008

Academic Editor: Freek Zijlstra

Copyright © 2008 Seong-Soo Roh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study is performed to investigate the inhibitory effects of Radix Adenophorae extract (RAE) on ovalbumin-induced asthma murine model. To study the anti-inflammatory and antiasthmatic effects of RAE, we examined the development of pulmonary eosinophilic inflammation and inhibitory effects of T cells in murine by RAE and cyclosporine A (CsA). We examined determination of airway hyperresponsiveness, flow cytometric analysis (FACS), enzyme-linked immunosorbent assay (ELISA), quantitative real time (PCR), hematoxylin-eosin staining, and Masson trichrome staining in lung tissue, lung weight, total cells, and eosinophil numbers in lung tissue. We demonstrated how RAE suppressed development on inflammation and decreased airway damage.