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			<g transform="matrix(.022,-0,0,-.022,.062,16.025)"><path id="x1D6FD" d="M558 587q0 -32 -14 -61t-40 -53.5t-48.5 -41t-54.5 -36.5q144 -51 144 -174q0 -55 -43.5 -108t-104.5 -87q-77 -42 -131 -42q-31 0 -54 20t-31 47l11 18q48 -29 108 -29q79 0 119.5 43t40.5 109t-44.5 107.5t-119.5 50.5l22 47q34 1 65 21q96 61 96 157q0 42 -24 67.5
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</svg> Release and Aggregates Differently from Intact ASC

<table>Hypothesized structure of fASC and vASC showing the PGR domain hinge.</table>

Mediators of Inflammation

fig6

Figure 6

Figure 6: A Splice Variant of ASC Regulates IL-1<svg     style="vertical-align:-4.698pt;width:13.15px;" id="M1" height="21.9375" version="1.1" viewBox="0 0 13.15 21.9375" width="13.15"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,16.025)"><path id="x1D6FD" d="M558 587q0 -32 -14 -61t-40 -53.5t-48.5 -41t-54.5 -36.5q144 -51 144 -174q0 -55 -43.5 -108t-104.5 -87q-77 -42 -131 -42q-31 0 -54 20t-31 47l11 18q48 -29 108 -29q79 0 119.5 43t40.5 109t-44.5 107.5t-119.5 50.5l22 47q34 1 65 21q96 61 96 157q0 42 -24 67.5
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</svg> Release and Aggregates Differently from Intact ASC 

Mediators of Inflammation

A Splice Variant of ASC Regulates IL-1 Release and Aggregates Differently from Intact ASC

Figure 6