Influence of Melatonin on Cerebrovascular Proinflammatory Mediators Expression and Oxidative Stress Following Subarachnoid Hemorrhage in Rabbits
Changes in the cross-sectional area of basilar arteries in the experimental SAH model. (a)–(d) Representative images of cross-sectional areas of the basilar arteries of the control rabbits or rabbits subjected to SAH alone or SAH plus injection with vehicle or melatonin. Severe vasospasm could be detected in the SAH group, which was attenuated in the SAH + melatonin group. (a) The control group; (b) the SAH group; (c) the SAH + vehicle group; (d) the SAH + melatonin group; (e): Histogram of the average cross-sectional area of the basilar arteries from different groups. There is a significant difference in the basilar artery cross-sectional area between the SAH and control groups. The basilar artery cross-sectional area was significantly increased in the SAH + melatonin group compared with the SAH or SAH + vehicle groups. Results are represented as means SD of six rabbits in each group. ** versus control group, ns versus SAH group; ## versus SAH + vehicle group.
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