Influence of Melatonin on Cerebrovascular Proinflammatory Mediators Expression and Oxidative Stress Following Subarachnoid Hemorrhage in Rabbits
Changes of inflammatory mediators in the basilar arteries as determined by ELISA in control group (), SAH group (), SAH + vehicle group (), and SAH + melatonin group (). SAH could induce the significantly increased concentrations of IL-1, TNF- and IL-6 in rabbit vascular tissue. In SAH + melatonin group, the arterial concentrations of IL-1, TNF- and IL-6 were markedly downregulated as compared with that of SAH or SAH + vehicle group. * and ** versus Control group, ns versus SAH group, # and ## versus SAH + vehicle group.
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