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Mediators of Inflammation
Volume 2009, Article ID 469169, 8 pages
http://dx.doi.org/10.1155/2009/469169
Research Article

Inflammation but Not Endothelial Dysfunction Is Associated with the Severity of Coronary Artery Disease in Dyslipidemic Subjects

1Instituto de Investigaciones, Fundación Cardiovascular de Colombia, Floridablanca, Colombia
2Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
3Facultad de Medicina, Universidad de Santander UDES, Bucaramanga, Colombia

Received 23 January 2009; Revised 11 March 2009; Accepted 15 April 2009

Academic Editor: Hidde Bult

Copyright © 2009 Christian F. Rueda-Clausen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Endothelial dysfunction and inflammation play a key role in the development of atherosclerosis. The present study evaluated endothelial function, inflammatory parameters, and carotid intima-media thickness (IMT) in dyslipidemic patients with or without coronary artery disease (CAD). Methods. Metabolic profile and inflammatory parameters were determined in dyslipidemic patients with (+CAD, ) and without ( CAD, ) symptomatic CAD. Endothelial function was evaluated by flow mediated dilatation (FMD) and plasma concentration of nitrites and nitrates. Carotid IMT was measured by ultrasound. Results. No significant differences were observed in anthropometric hemodynamic or metabolic parameters between the groups. After adjusting by age and medication usage, some inflammatory markers were significantly higher in +CAD; however no significant differences in FMD or plasma levels of nitrites were observed. Conclusions. In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.