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Mediators of Inflammation
Volume 2009, Article ID 561532, 5 pages
http://dx.doi.org/10.1155/2009/561532
Clinical Study

Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India

1Institute of Pathology (ICMR), Safdarjung Hospital Campus, P.O. Box 4909, New Delhi 110 029, India
2Department of Cardio Thoracic & Vascular Surgery, Safdarjung Hospital, New Delhi 110 029, India

Received 5 September 2008; Revised 15 December 2008; Accepted 12 January 2009

Academic Editor: Yvette Mandi

Copyright © 2009 Hem Chandra Jha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Plasma inflammatory markers have been shown to be predictors for cardiovascular risk, however, there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients (CAD pts) positive for C. pneumoniae IgA and high sensitive C-reactive protein (hsCRP) which may help in better understanding of disease pathogenesis. A total of 192 patients and 192 controls attending the Cardiology Outpatient Department of Safdarjung Hospital were enrolled. The levels of plasma circulatory inflammatory markers were evaluated by ELISA. The levels of circulatory plasma markers (IL-4, IL-8, IL-13, ICAM-1, and VCAM-1) were significantly higher, whereas, levels of IL-10 and IFN- were significantly lower in CAD pts compared to healthy controls. The levels of IL-4, IL-8, and ICAM-1 ( , .015, and .048) were significantly higher, however, IL-10 and IFN- were significantly lower ( , ) in C. pneumoniae IgA positive CAD pts. The levels of IL-4, IL-8, IL-13, ICAM-1, and VCAM-1 were higher but not significant and levels of IL-10 and IFN- were significantly ( , ) lower in hsCRP positive CAD pts. Our study suggested that circulatory cytokines, namely, IL-4, IL-8, and adhesive molecules like ICAM-1 were enhanced after infection with C. pneumoniae whereas in contrast to this IL-10 and IFN- were lowered. Suggesting the important role of these cytokines in progression of CAD.