Mediators of Inflammation / 2009 / Article / Fig 4

Research Article

Influence of Epinastine Hydrochloride, an H 1 -Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo

Figure 4

Influence of nasal antigenic challenge on inflammatory cytokine appearance in nasal lavage fluid obtained from mice instilled nasally with Dermatophagoides farinae (Der f)-pulsed dendritic cells. BALB/c mice were instilled nasally with Der f-pulsed and 25 ng/mL epinastine hydrochloride (EP)-treated DCs. Nasal lavage was performed 24 hours after the final Der f allergen exposure. The data are expressed as the mean pg/mL ± SE of five mice. This is one of two different experiments, which gave reproducible results. Der f alone: Der f allergen exposure alone; N. DC alone: nonpulsed DC instilled; N. DC + Der f: nonpulsed DC instilled and Der f allergen exposure; P. DC alone: Der f-pulsed DC instilled; P. DC + Der f: Der f-pulsed DC and Der f allergen exposure; P. DC + Der f + EP: Der f-pulsed, EP-treated DC and Der f exposure. N. D.: not detected.

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