Influence of Epinastine Hydrochloride, an -Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo
Figure 4
Influence of nasal
antigenic challenge on inflammatory cytokine appearance in nasal lavage fluid
obtained from mice instilled nasally with Dermatophagoides
farinae (Der f)-pulsed dendritic
cells. BALB/c mice were instilled nasally with Der f-pulsed and 25 ng/mL epinastine hydrochloride (EP)-treated
DCs. Nasal lavage was performed 24 hours after the final Der f allergen exposure. The data are expressed as the mean pg/mL ±
SE of five mice. This is one of two different experiments, which gave
reproducible results. Der f alone: Der f allergen exposure alone; N. DC
alone: nonpulsed DC instilled; N. DC + Der
f: nonpulsed DC instilled and Der f allergen exposure; P. DC alone: Der f-pulsed
DC instilled; P. DC + Der f: Der f-pulsed DC and Der f allergen exposure; P. DC + Der f + EP: Der f-pulsed,
EP-treated DC and Der f exposure.
N. D.: not detected.
