Influence of Epinastine Hydrochloride, an -Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo
Influence of nasal
antigenic challenge on inflammatory cytokine appearance in nasal lavage fluid
obtained from mice instilled nasally with Dermatophagoides
farinae (Der f)-pulsed dendritic
cells. BALB/c mice were instilled nasally with Der f-pulsed and 25 ng/mL epinastine hydrochloride (EP)-treated
DCs. Nasal lavage was performed 24 hours after the final Der f allergen exposure. The data are expressed as the mean pg/mL ±
SE of five mice. This is one of two different experiments, which gave
reproducible results. Der f alone: Der f allergen exposure alone; N. DC
alone: nonpulsed DC instilled; N. DC + Der
f: nonpulsed DC instilled and Der f allergen exposure; P. DC alone: Der f-pulsed
DC instilled; P. DC + Der f: Der f-pulsed DC and Der f allergen exposure; P. DC + Der f + EP: Der f-pulsed,
EP-treated DC and Der f exposure.
N. D.: not detected.
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