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Mediators of Inflammation
Volume 2009 (2009), Article ID 760837, 7 pages
http://dx.doi.org/10.1155/2009/760837
Research Article

Myeloperoxidase Content is a Marker of Systemic Inflammation in a Chronic Condition: The Example Given by the Periodontal Disease in Rats

1Department of Pharmacology, Federal University of Minas Gerais, 31270-100 Belo Horizonte, Brazil
2Department of Health Sciences, Newton Paiva University Center, 30460-720 Belo Horizonte, Brazil
3Department of Pathology, Federal University of Minas Gerais, 31270-100 Belo Horizonte, Brazil

Received 26 June 2009; Accepted 5 October 2009

Academic Editor: Francesco Marotta

Copyright © 2009 Celso Martins Queiroz-Junior et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The study aimed to evaluate the suitability of myeloperoxidase (MPO) content as a local indicator of chronic inflammation, using the periodontal disease model. Anesthetized adult male Holtzman rats had their second left maxilar molar tied by a thread for 11 days and were then killed. Blood samples and photographic images from histopathological inflamed and noninflamed (contralateral) neighboring gingivomucosal specimens were collected for cell counts and MPO level analysis. Diseased animals were also treated with pharmacological tools such as the anti-inflammatory drug celecoxib or the opioid morphine. Increased blood neutrophils and local cell numbers characterized diseased animals. However, local MPO content was increased in inflamed and noninflamed tissues from diseased animals. Celecoxib and morphine reduced blood neutrophils and bilateral MPO content, but only celecoxib reduced local cell numbers in diseased animals. It is concluded that MPO content is a good indicator of a systemic rather than a local inflammation in a chronic inflammatory condition.