Chemokine Receptor and Ligand Upregulation in the Diaphragm
during Endotoxemia and Pseudomonas Lung Infection
Figure 2
Effects of endotoxemia on RANTES and MIP-1α gene expression in the diaphragm and limb muscle. (a) Ribonuclease protection assay demonstrating RANTES and MIP-1α gene expression in the diaphragm and TA at 24 hours following LPS or saline administration. (b) Quantification of RANTES and MIP-1α mRNA levels at different time points after LPS delivery. All data are group means ± SE, mice per group. Data are normalized to the L32 housekeeping gene. for comparisons between diaphragm and TA within the same condition (LPS or sham control); for comparisons between LPS- and sham control (saline)-treated mice within the same type of muscle (diaphragm or TA).
