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Mediators of Inflammation
Volume 2009 (2009), Article ID 932515, 5 pages
http://dx.doi.org/10.1155/2009/932515
Clinical Study

Efficacy of Clopidrogel on Reperfusion and High-Sensitivity C-Reactive Protein in Patients with Acute Myocardial Infarction

1Department of Cardiology, Faculty of Medicine, Fırat University, 23100 Elazığ, Turkey
2Cardiology Clinic, Harput State Hospital, 23110 Elazığ, Turkey

Received 2 July 2008; Revised 30 December 2008; Accepted 4 March 2009

Academic Editor: Charles Larry Campbell

Copyright © 2009 Mehmet Akbulut et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the effects of clopidogrel on reperfusion and inflammatory process in STEMI. A total of 175 STEMI patients with similar clinical characteristics were included to this study. One was the standard pharmacological reperfusion therapy group (group 1, n : 90), who received 300 mg aspirin, 70 U/kg bolus, and 12 U/kg/hr continuous infusion of unfractioned heparin and accelerated t-PA. Clopidogrel 450 mg loading and 75 mg/d thereafter was added to standard reperfusion therapy in the other group (group 2, n : 85). The ST-segment resolution, CK-MB, and high-sensitive CRP (hs-CRP) parameters were measured. Complete ST resolution was observed in 32 patients (36.8%) in group 1 and 53 patients (63.8%) in group 2 ( 𝑃 < . 0 0 1 ). Also in the first 24 hours, the CK-MB levels of patients in group 1 were significantly higher than those of group 2 ( 𝑃 = . 0 0 1 ). The hs-CRP values were greater in group 1 than group 2 at 48th hour (gruop 1: 9 . 4 ± 0 . 1  mg/L, group 2: 3 . 7 ± 1 . 4  mg/L; 𝑃 = . 0 0 0 ). We concluded that adding clopidogrel to standard treatment in STEMI patients provided early reperfusion and suppression of inflammatory response.