Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

Table 1

Metabolic characteristics of normotensive and hypertensive animals.

Determination	Wistar rats (n = 14)	SHR (n = 28)	P value
Body weight (g)	$283.6\pm 9.4$	$303.3\pm 2.6$	.001
Free fatty acids (mg/dL)	$\mathrm{\hspace{0.17em}\hspace{0.17em}}20.8\pm 1.7$	$\mathrm{\hspace{0.17em}\hspace{0.17em}}20.3\pm 0.9$	.776
Triglycerides (mg/dL)	$\mathrm{\hspace{0.17em}\hspace{0.17em}}105.3\pm 19.2$	$129.5\pm 6.7$	.05
Total cholesterol (mg/dL)	$113.5\pm 6.4$	$134.1\pm 3.2$	.002
Glucose (mg/dL)	$133.4\pm 0.7$	$205.5\pm 0.5$	.002
Insulin (ng/mL)	$\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}1.3\pm 0.3$	$\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}3.0\pm 0.3$	.001
Leptin (ng/mL)	$\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}2.5\pm 0.1$	$\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}3.1\pm 0.1$	.05
TBARS ($\mu$mol/L)	$\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}1.4\pm 0.2$	$\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}\mathrm{\hspace{0.17em}\hspace{0.17em}}2.2\pm 0.2$	.025

SHR, spontaneously hypertensive rats; TBARS, thiobarbituric acid reactive substances. Values presented as the mean $\pm$ SEM. Differences between groups were analysed by Student’s t-test. Bold values are statistically significant P values among groups.