Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study
Table 3
Significance of association tests of ALOX12, ALOX15, ALOX5, and ALOX5AP SNPs with measures of atherosclerosis, independent of epidemiologic risk factors.
P-values
Gene
LD Block
SNP
CorCP
CarCP
AorCP
IMT
ALOX12
rs9904779
0.308
0.853
0.533
0.874
(1 block)
1
rs2292350
0.523
0.552
0.436
0.827
rs2271316
0.061
0.839
0.555
0.683
ALOX15
rs11568061
0.654
0.334
0.142
0.415
(2 blocks)
2
rs2515889
0.628
0.413
0.371
0.245
1
rs2619112
0.872
0.117
0.425
0.296
ALOX5
1
rs745986
0.183
0.743
0.157
0.478
(8 blocks)
2
rs2115819
0.09
0.553
0.108
0.286
3
rs892691
0.67
0.192
0.74
0.849
4
rs3780906
0.603
0.203
0.541
0.09
7
rs2291427
0.114
0.964
0.423
0.336
ALOX5AP
rs17244974
0.251
0.572
0.492
0.173
(5 blocks)
1
rs4769055
0.201
0.805
0.242
0.376
2
rs10507391
0.288
0.085
0.648
0.473
3
rs9551960
0.591
0.136
0.174
0.591
4
rs9506352
0.097
0.369
0.188
0.511
5
rs4769060
0.073
0.378
0.456
0.299
Analyses performed using the quantitative pedigree disequilibrium test (QPDT); -values adjusted for age, gender, diabetes status, smoking status, lipid lowering medication use, BMI, estrogen use, aspirin use, and hypertension medication use.
