Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study
Table 4
Genotypic means (± SD) of lipoxygenase variants in ALOX5, ALOX5AP, and ALOX12 with atherosclerosis phenotypes.
Gene
SNP
1/1
1/2
2/2
CorCP
ALOX5
rs2115819
1007 ± 2088
1211 ± 2489
1540 ± 2893
181
264
454
(247)
(352)
(145)
ALOX12
rs2271316
1065 ± 1639
1109 ± 2299
1423 ± 3155
308
223
262
(134)
(341)
(208)
ALOX5AP
rs9506352
1101 ± 2142
1188 ± 2416
1672 ± 3721
265
229
254
(331)
(332)
(64)
rs4769060
996 ± 1767
1244 ± 2565
1404 ± 3086
242
264
161
(238)
(377)
(130)
CarCP
ALOX5AP
rs10507391
360 ± 702
313 ± 694
216 ± 405
60
71
5
(358)
(368)
(89)
AorCP
ALOX5
rs2115819
3208 ± 4350
2908 ± 3791
5318 ± 5563
1256
1338
3158
(188)
(291)
(105)
IMT
ALOX5
rs3780906
0.666 ± 0.127
0.675 ± 0.129
0.687 ± 0.139
0.649
0.654
0.645
(436)
(348)
(75)
The mean phenotypic value for each genotype (1/1, 2/1, 2/2) is provided with the median and the number of individuals () with each genotype included in the analysis; numbers vary based upon those with genotypic and phenotypic data.
