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Mediators of Inflammation
Volume 2010, Article ID 171023, 7 pages
Research Article

Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women

1Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo 173-0015, Japan
2Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, Japan
3School of Physical Education, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan
4Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan

Received 20 July 2010; Revised 21 October 2010; Accepted 1 December 2010

Academic Editor: Giamila Fantuzzi

Copyright © 2010 Kishiko Ogawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA ( ), HSP70, IGF-I, and insulin ( ). The training-induced reductions in CRP and TNF-α were significantly ( , ) associated with increased muscle thickness ( , ), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.