Rhizoma coptidis Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NF𝜅B-Dependent Pathway

Figure 1

Morphology of RAW 264.7 cells cultured in standard medium (a), after stimulation with LPS (b), after LPS-stimulation and exposure to either total extract of Rhizoma coptidis (dilution $1:5$) (c), or to berberine (10⁻⁴ mol) (d). Activation with LPS resulted in moderate reduction of total cell numbers and moderate altered cell morphology. No apparent morphologic changes were observed between the different LPS-stimulated cells.

(a)

(b)

(c)

(d)