Research Article

Disruption of Nrf2 Enhances the Upregulation of Nuclear Factor-kappaB Activity, Tumor Necrosis Factor- , and Matrix Metalloproteinase-9 after Spinal Cord Injury in Mice

Figure 6

MMP-9 expression by Western blot analysis in spinal cord homogenates from sham and injured Nrf2 (+/+) and Nrf2 (−/−) mice. (a) Representative X-ray film shows MMP-9 expression by Western blot analysis at 24 hours after SCI in sham and injured Nrf2 (+/+) and Nrf2 (−/−) mice. (b) The figure indicates that higher MMP-9 expression levels were found in Nrf2 (−/−) mice than in Nrf2 (+/+) mice at 24 hours after SCI. Bars represent mean ± S.E. (n=6, each group). *P<.01 versus sham control of the same genotype. #P<.01 versus injured wild-type mice.
238321.fig.006a
(a)
238321.fig.006b
(b)