Inflammation, HIF-1, and the Epigenetics That Follows

Figure 1

A vicious circuit could be established when HIF-1 activates, on recruited inflammatory cells, specific cytokines, such as IL-10, TNF, HIF1 (on macrophages in particular), or IL-4, IL13 (from mastocytes, eosinophils, or other cells). This event would create new inflammation followed by new hypoxia again.