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Mediators of Inflammation
Volume 2010 (2010), Article ID 268547, 10 pages
Research Article

High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.

1Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
2Biotech Center, Cook College, Rutgers University, New Brunswick, NJ 08901-8554, USA
3Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, NJ 08901-8554, USA

Received 1 December 2009; Revised 20 January 2010; Accepted 21 January 2010

Academic Editor: Giamila Fantuzzi

Copyright © 2010 Pierre Watcho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-sfat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed obesity, moderate nonfasting hyperglycemia, nerve conduction deficit, thermal and mechanical hypoalgesia, and tactile allodynia. They displayed 12/15-lipoxygenase overexpression, 12(S)-hydroxyeicosatetraenoic acid accumulation, and nitrosative stress in peripheral nerve and spinal cord. PMI-5011 (500  , 7 weeks) normalized glycemia, alleviated nerve conduction slowing and sensory neuropathy, and reduced 12/15-lipoxygenase upregulation and nitrated protein expression in peripheral nervous system. PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease.