High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.

Figure 3

Representative Western blot analyses ((a), (c), (e), (g)) and content (densitometry, ((b), (d), (f), (h))) of mouse sciatic nerve ((a)–(d)) and spinal cord ((e)–(h)) nitrated protein expressions after 16-week ((a), (b) and (e), (f)) and 23-week ((c), (d) and (g), (h)) feedings with normal chow or high-fat diet with or without PMI-5011. NC: normal chow, HF: high fat diet, T: treatment. Mean$\pm$SEM, $n=7\text{-}8$ per group. ${}^{*,**}P<.05$ and $<.01$ versus mice fed NC; ${}^{\S }P<.05$ versus the baseline value (16-wk time point); ${}^{\#,\#\#}P<.05$ and $<.01$ versus mice fed HFD.