High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.

Table 2

Motor and sensory nerve conduction velocities in normal chow and high fat diet-fed mice maintained with and without PMI-5011 treatment.

Groups	NC	$\text{NC}+\text{T}$	HFD	$\text{HFD}+\text{T}$
Variables
Baseline (prior to the beginning of HFD feeding)
MNCV, ms^−1	$50.8\pm 0.75$
SNCV, ms^−1	$38.4\pm 0.71$
16-wk time point (prior to PMI-5011 treatment)
MNCV, ms^−1	$51.8\pm 0.87$		$46.3\pm 0.77{}^{**}$
SNCV, ms^−1	$39.1\pm 0.65$		$33.8\pm 0.81{}^{**}$
23-wk time point (final measurements)
MNCV, ms^−1	$51.4\pm 1.78$	$52.3\pm 2.14$	$45.9\pm 1.18{}^{*}$	$51.0\pm 1.45{}^{\S ,\#}$
SNCV, ms^−1	$38.7\pm 0.92$	$37.3\pm 1.08$	$33.6\pm 1.14{}^{**}$	$36.8\pm 0.92{}^{\S ,\pounds ,\#}$

Data are expressed as $\text{Mean}\pm \text{SEM}\text{,}$$n=10\text{–}12$ per group. NC: normal chow; T: treatment; HFD: high fat diet; MNCV: motor nerve conduction velocity; SNCV: sensory nerve conduction velocity. ${}^{*,**}P<.05$ and $<.01$ versus mice fed NC; ${}^{\S }P<.05$ versus the baseline value (16-wk time point); ${}^{\pounds }P<.05$ versus mice fed NC (16-wk time point); ${}^{\#}P<.05$ versus untreated mice fed HFD (23-wk time point).