Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate

Figure 4

A few CD123+ pDCs, as the one indicated by the thin arrow, in the inflammatory infiltrate of a Darier’s disease case (a). In pemphigus vulgaris, CD123+ pDCs are more numerous, usually found in the dermis and/or inside the bulla ((b), thin arrow). A lichen ruber planus skin sample showing a high number of single or grouped CD123+ pDCs in the dermal inflammatory infiltrate (c). The endothelium of vessels ((a), (b), (c), thick arrows) is also weakly stained by the antiCD123 antibody. Immunohistochemistry; original magnification, $\times$200. Scale bar: A = 35 $\mu$m; B, C = 45 $\mu$m; Chromogen: fuchsin.