Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity

Figure 1

In the human body, carbon monoxide is formed at a rate of 16.4 $\mu$mol/h and daily production can reach 500 $\mu$M (Piantadosi, Antioxid Redox Signal, 2002, 4:259-70). About 86% comes from HO-catalyzed degradation of heme while 14% from lopid peroxidation xenobiotics and other sources.