Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model
Figure 1
Macroscopic histomorphological evaluation of bladders. All the bladders from the control (a) and CEL (data not shown) treated rats have revealed a pattern of normality, with absence of any type of malignity. In the BBN group (b), 65.0% of the rats had bladder tumors, almost all easily seen by macroscopic analysis. The bladder walls were thicker, with new or enlarged small vessels, suggesting neo-angiogenesis, and there was unequivocal formation of tumor (some bladder presented more than one tumor). In the preventive CEL (CEL+BBN-P group) treatment (c), except in one case, all bladders shows a similar pattern to those seen for the control or CEL rats, with macroscopically unrecognized signs of abnormality. However, in the curative CEL (BBN+CEL-C group) use (d), there was 75% of tumor incidence, with even more malignant neoplasic lesions.
