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Mediators of Inflammation
Volume 2010, Article ID 453892, 11 pages
Review Article

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan

Received 28 September 2009; Accepted 13 November 2009

Academic Editor: Giamila Fantuzzi

Copyright © 2010 Hideaki Kaneto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic 𝛽 -cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate 𝛽 -cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.