Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2010, Article ID 473540, 9 pages
http://dx.doi.org/10.1155/2010/473540
Clinical Study

Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients

1Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany
2Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany

Received 10 March 2010; Accepted 4 May 2010

Academic Editor: Oreste Gualillo

Copyright © 2010 Alexander Koch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. J. Van Cromphaut, I. Vanhorebeek, and G. Van den Berghe, “Glucose metabolism and insulin resistance in sepsis,” Current Pharmaceutical Design, vol. 14, no. 19, pp. 1887–1899, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. B. W. Whitcomb, E. K. Pradhan, A. G. Pittas, M.-C. Roghmann, and E. N. Perencevich, “Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations,” Critical Care Medicine, vol. 33, no. 12, pp. 2772–2777, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. G. E. Umpierrez, S. D. Isaacs, N. Bazargan, X. You, L. M. Thaler, and A. E. Kitabchi, “Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 978–982, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. M. K. Badman and J. S. Flier, “The adipocyte as an active participant in energy balance and metabolism,” Gastroenterology, vol. 132, no. 6, pp. 2103–2115, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. S. E. Shoelson, L. Herrero, and A. Naaz, “Obesity, inflammation, and insulin resistance,” Gastroenterology, vol. 132, no. 6, pp. 2169–2180, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. J. M. Friedman and J. L. Halaas, “Leptin and the regulation of body weight in mammals,” Nature, vol. 395, no. 6704, pp. 763–770, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. J. K. Elmquist, C. F. Elias, and C. B. Saper, “From lesions to leptin: hypothalamic control of food intake and body weight,” Neuron, vol. 22, no. 2, pp. 221–232, 1999. View at Google Scholar · View at Scopus
  8. S. H. Bates and M. G. Myers Jr., “The role of leptin receptor signaling in feeding and neuroendocrine function,” Trends in Endocrinology and Metabolism, vol. 14, no. 10, pp. 447–452, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. P. J. Havel, S. Kasim-Karakas, W. Mueller, P. R. Johnson, R. L. Gingerich, and J. S. Stern, “Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 12, pp. 4406–4413, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. M. J. Moreno-Aliaga, K. L. Stanhope, and P. J. Havel, “Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3T3-L1 adipocytes,” Biochemical and Biophysical Research Communications, vol. 283, no. 3, pp. 544–548, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Margetic, C. Gazzola, G. G. Pegg, and R. A. Hill, “Leptin: a review of its peripheral actions and interactions,” International Journal of Obesity, vol. 26, no. 11, pp. 1407–1433, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Bjørbaek and B. B. Kahn, “Leptin signaling in the central nervous system and the periphery,” Recent Progress in Hormone Research, vol. 59, pp. 305–331, 2004. View at Google Scholar · View at Scopus
  13. J. Ockenga, U. J. F. Tietge, K. H. Boker, M. P. Manns, G. Brabant, and M. J. Bahr, “Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis,” Alimentary Pharmacology and Therapeutics, vol. 25, no. 11, pp. 1301–1309, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. B. N. Finck, K. W. Kelley, R. Dantzer, and R. W. Johnson, “In vivo and in vitro evidence for the involvement of tumor necrosis factor-α in the induction of leptin by lipopolysaccharide,” Endocrinology, vol. 139, no. 5, pp. 2278–2283, 1998. View at Google Scholar · View at Scopus
  15. C. Grunfeld, C. Zhao, J. Fuller et al., “Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters: a role for leptin in the anorexia of infection,” Journal of Clinical Investigation, vol. 97, no. 9, pp. 2152–2157, 1996. View at Google Scholar · View at Scopus
  16. O. A. Gressner, A. Koch, E. Sanson, C. Trautwein, and F. Tacke, “High C5a levels are associated with increased mortality in sepsis patients—no enhancing effect by actin-free Gc-globulin,” Clinical Biochemistry, vol. 41, no. 12, pp. 974–980, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Langouche, S. Vander Perre, J. Frystyk, A. Flyvbjerg, T. K. Hansen, and G. Van den Berghe, “Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin,” Critical Care, vol. 13, no. 4, article R112, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Chen, F. Li, J. Li et al., “Induction of leptin resistance through direct interaction of C-reactive protein with leptin,” Nature Medicine, vol. 12, no. 4, pp. 425–432, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Coppari, M. Ichinose, C. E. Lee et al., “The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity,” Cell Metabolism, vol. 1, no. 1, pp. 63–72, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. G. J. Morton, R. W. Gelling, K. D. Niswender, C. D. Morrison, C. J. Rhodes, and M. W. Schwartz, “Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons,” Cell Metabolism, vol. 2, no. 6, pp. 411–420, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Koch, O. A. Gressner, E. Sanson, F. Tacke, and C. Trautwein, “Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients,” Critical Care, vol. 13, no. 3, article R95, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Sunden-Cullberg, T. Nystrom, M. L. Lee et al., “Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock,” Critical Care Medicine, vol. 35, no. 6, pp. 1536–1542, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Jeevanandam, C. K. Begay, and S. R. Petersen, “Plasma leptin levels in trauma patients: effect of adjuvant recombinant human growth hormone in intravenously fed multiple trauma patients,” Journal of Parenteral and Enteral Nutrition, vol. 22, no. 6, pp. 340–346, 1998. View at Google Scholar · View at Scopus
  24. P. Cohen, C. Zhao, X. Cai et al., “Selective deletion of leptin receptor in neurons leads to obesity,” Journal of Clinical Investigation, vol. 108, no. 8, pp. 1113–1121, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. I. S. Farooqi, G. Matarese, G. M. Lord et al., “Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency,” Journal of Clinical Investigation, vol. 110, no. 8, pp. 1093–1103, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. I. S. Farooqi, T. Wangensteen, S. Collins et al., “Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor,” The New England Journal of Medicine, vol. 356, no. 3, pp. 237–247, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. S. H. Bates, R. N. Kulkarni, M. Seifert, and M. G. Myers Jr., “Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis,” Cell Metabolism, vol. 1, no. 3, pp. 169–178, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. J. H. Henriksen, J. J. Holst, S. Moller, K. Brinch, and F. Bendtsen, “Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal,” Hepatology, vol. 29, no. 6, pp. 1818–1824, 1999. View at Publisher · View at Google Scholar · View at Scopus