DAMPening Inflammation by Modulating TLR Signalling

Figure 1

Endogenous TLR activators. TLRs are activated by damage-associated molecular patterns (DAMPs) including intracellular molecules released in the extracellular milieu by activated or necrotic cells and extracellular matrix molecules either upregulated upon injury or degraded following tissue damage. Known endogenous TLR activators are listed based on their biochemical nature.