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Mediators of Inflammation
Volume 2010 (2010), Article ID 758656, 5 pages
http://dx.doi.org/10.1155/2010/758656
Review Article

Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity

Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Michael White Diabetes Centre, 220-236 Analby Road, Hull Royal Infirmary, Hull HU3 2JZ, UK

Received 27 October 2009; Accepted 18 March 2010

Academic Editor: Giuseppe Matarese

Copyright © 2010 Thozhukat Sathyapalan and Stephen L. Atkin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age group and is associated with a higher cardiovascular risk. Obesity, mainly visceral adiposity, is prevalent in patients with PCOS. Obesity is associated with low-grade inflammation and raised inflammatory cytokines, both of which are also described in patients with PCOS. In this paper, the potential relationships between fat distribution, adipocyte dysfunction and, altered inflammatory markers in patients with PCOS have been discussed.