Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of ob/ob Mice

Table 6

Genes involved in oxidative stress and inflammatory responses altered by leptin in gastrocnemius muscle of ob/ob mice independently of food intake restriction.

GeneBank Number	Gene symbol	Gene name	Fold change
Genes downregulated by leptin
NM_023695	Crybb1	Crystallin, $\beta$ B1	0.51
NM_021422	Dnaja4	Heat shock protein, DNAJ-like 4	0.63
NM_019739	Foxo1	Forkhead box O1	0.34
NM_008300	Hspa4	Heat shock protein 4	0.64
NM_013868	Hspb7	Heat shock protein family, member 7	0.34
NM_010592	Jund1	Jun D proto-oncogene	0.50
NM_008456	Klk5	Kallikrein 5	0.46
NM_008491	Lcn2	Lipocalin 2	0.34
NM_008631	Mt4	Metallothionein 4	0.63
NM_026346	MAFbx	Muscle atrophy F box	0.37
AK_052911	MuRF1	M muscle RING finger 1	0.29
NM_011459	Serpinb8	Serine (or cysteine) proteinase inhibitor, clade B, member 8	0.38
NM_011459	Serpinb8	Serine (or cysteine) proteinase inhibitor, clade B, member 8	0.59
NM_008871	Serpine1	Serine (or cysteine) proteinase inhibitor, clade E, member 1	0.42
Genes upregulated by leptin
NM_009735	B2m	$\beta$ -2-microglobulin	1.92
NM_010361	Gstt2	Glutathione S-transferase, $\theta$ 2	1.94
NM_010379	H2-Ab1	Histocompatibility 2, class II antigen A, $\beta$ 1	4.72
NM_010379	H2-Ab1	Histocompatibility 2, class II antigen A, $\beta$ 1	3.66
NM_010386	H2-DMa	Histocompatibility 2, class II, locus Dma	2.35
NM_010387	H2-DMb1	Histocompatibility 2, class II, locus Mb1	3.31
NM_010382	H2-Eb1	Histocompatibility 2, class II antigen E $\beta$	4.65
NM_013559	Hsp105	Heat shock protein 105	1,79
AK220167	Hspa4	MKIAA4025 protein	1,59
NM_207105	Rmcs1	Histocompatibility 2, class II antigen A, $\beta$ 1	4.24
NM_207105	Rmcs1	Histocompatibility 2, class II antigen A, $\beta$ 1	4.17
NM_009255	Serpine2	Serine (or cysteine) proteinase inhibitor, clade E, member 2	1.53
NM_009825	Serpinh1	Serine (or cysteine) proteinase inhibitor, clade H, member 1	2.21
NM_145533	Smox	Spermine oxidase	4.67

Differential expression of genes is indicated as fold changes presenting only the genes which were significantly different ($P<.05$) between the leptin-treated and the pair-fed ob/ob groups.