Regulation of I𝜅B𝛼 Function and NF-𝜅B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

Figure 3

Regulation of I𝜅B𝛼 and I𝜅B𝛽. A cartoon representing the most critical intracellular events leading to NF-𝜅B transcriptional activation. Interaction between diverse ligands and their receptors eventually leads to activation of the IKK complex, which allows I𝜅B𝛼 and I𝜅B𝛽 phosphorylation in the cytosol. This phosphorylation step is followed by I𝜅B𝛼, but not I𝜅B𝛽, ubiquitination, and subsequently, I𝜅B𝛼 and I𝜅B𝛽 are subjected to proteolytic degradation. Once I𝜅B𝛼 and I𝜅B𝛽 molecules are degraded, NF-𝜅B dimers are liberated, and they translocate to the nucleus subsequent to unmasking of their NLS. Once in the nucleus, NF-𝜅B dimers bind to 𝜅B sites within the promoter/enhancer regions of their target genes, driving gene transactivation.