Regulation of I<svg style="vertical-align:-0.0pt;width:13.4375px;" id="M1" height="10.0125" version="1.1" viewBox="0 0 13.4375 10.0125" width="13.4375"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.0125)">
		<g transform="translate(72,-63.99)">
			<text transform="matrix(1,0,0,-1,-71.95,64.04)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝜅</tspan>
			</text>

		</g>
	</g>
</svg>B<svg style="vertical-align:-0.18pt;width:12.7625px;"  height="10.2375" version="1.1" viewBox="0 0 12.7625 10.2375" width="12.7625"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.2375)">
		<g transform="translate(72,-63.81)">
			<text transform="matrix(1,0,0,-1,-71.95,64.04)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝛼</tspan>
			</text>

		</g>
	</g>
</svg> Function and NF-<svg style="vertical-align:-0.0pt;width:13.4375px;"  height="10.0125" version="1.1" viewBox="0 0 13.4375 10.0125" width="13.4375"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.0125)">
		<g transform="translate(72,-63.99)">
			<text transform="matrix(1,0,0,-1,-71.95,64.04)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝜅</tspan>
			</text>

		</g>
	</g>
</svg>B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

<table>Amino Acid Sequence Comparison between<svg height="10.625" id="M776" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 39.0625 10.625" width="39.0625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.625)">
<g transform="translate(72,-63.5)">
<text transform="matrix(1,0,0,-1,-67.78,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">I</tspan>
</text>
<text transform="matrix(1,0,0,-1,-63.62,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜅</tspan>
</text>
<text transform="matrix(1,0,0,-1,-56.19,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">B</tspan>
</text>
<text transform="matrix(1,0,0,-1,-47.85,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
</text>
</g>
</g>
</svg> and <svg height="13.425" id="M777" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 33.762501 13.425" width="33.762501" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">I</tspan>
</text>
<text transform="matrix(1,0,0,-1,-67.79,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜅</tspan>
</text>
<text transform="matrix(1,0,0,-1,-60.36,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">B</tspan>
</text>
<text transform="matrix(1,0,0,-1,-52.02,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
</text>
</g>
</g>
</svg>. (a) Alignment of amino acid sequences of mouse I<svg height="7.0124998" id="M778" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 9.4125004 7.0124998" width="9.4125004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.0125)">
<g transform="translate(72,-66.39)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜅</tspan>
</text>
</g>
</g>
</svg>B<svg height="7.1750002" id="M779" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
</text>
</g>
</g>
</svg> and I<svg height="7.0124998" id="M780" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 9.4125004 7.0124998" width="9.4125004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.0125)">
<g transform="translate(72,-66.39)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜅</tspan>
</text>
</g>
</g>
</svg>B<svg height="13.425" id="M781" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
</text>
</g>
</g>
</svg> is shown. The six highly conserved ANK repeats in both proteins are highlighted in grey, yellow, green, red, pink, and blue, respectively. (b) A cartoon illustrating a comparison of the slightly different structural domain organizations of mouse I<svg height="7.0124998" id="M782" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 9.4125004 7.0124998" width="9.4125004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.0125)">
<g transform="translate(72,-66.39)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜅</tspan>
</text>
</g>
</g>
</svg>B<svg height="7.1750002" id="M783" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
</text>
</g>
</g>
</svg> and I<svg height="7.0124998" id="M784" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 9.4125004 7.0124998" width="9.4125004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.0125)">
<g transform="translate(72,-66.39)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜅</tspan>
</text>
</g>
</g>
</svg>B<svg height="13.425" id="M785" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
</text>
</g>
</g>
</svg> proteins. The signal-induced kinase domain, six ANK repeats, and PEST domain of each protein are shown.</table>

Mediators of Inflammation

fig4

Figure 4

Figure 4: Regulation of I<svg style="vertical-align:-0.0pt;width:13.4375px;" id="M1" height="10.0125" version="1.1" viewBox="0 0 13.4375 10.0125" width="13.4375"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.0125)">
		<g transform="translate(72,-63.99)">
			<text transform="matrix(1,0,0,-1,-71.95,64.04)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝜅</tspan>
			</text>

		</g>
	</g>
</svg>B<svg style="vertical-align:-0.18pt;width:12.7625px;"  height="10.2375" version="1.1" viewBox="0 0 12.7625 10.2375" width="12.7625"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.2375)">
		<g transform="translate(72,-63.81)">
			<text transform="matrix(1,0,0,-1,-71.95,64.04)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝛼</tspan>
			</text>

		</g>
	</g>
</svg> Function and NF-<svg style="vertical-align:-0.0pt;width:13.4375px;"  height="10.0125" version="1.1" viewBox="0 0 13.4375 10.0125" width="13.4375"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.0125)">
		<g transform="translate(72,-63.99)">
			<text transform="matrix(1,0,0,-1,-71.95,64.04)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝜅</tspan>
			</text>

		</g>
	</g>
</svg>B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages 

Figure 4 | Regulation of I
	
		
			
				𝜅
			

		
	
B
	
		
			
				𝛼
			

		
	
 Function and NF-
	
		
			
				𝜅
			

		
	
B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages 

Mediators of Inflammation

Regulation of I 𝜅 B 𝛼 Function and NF- 𝜅 B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

Figure 4

Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages