The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat
Metabolic function: (a) Glucose-tolerance test (GTT) performed in candesartan-treated (CAN) or untreated (c) lean and obese rats at 13 weeks of treatment ( per body type/treatment). Blood glucose levels measured at different time points in response to 50% dextrose solution (3 ml/) given intraperitoneally. Area under the curve was higher for the obese rats compared to the lean, and a significant interaction was found between body type and treatment by 2-way ANOVA (). (b) Blood glucose and (c) plasma insulin levels at the end of 14 weeks of treatment ( per body type/treatment) were different between the body types by 2-way ANOVA (); 14 weeks of CAN treatment did not affect these levels. * indicates a significant difference () from lean control mean and # from obese control mean, by unpaired -test.