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Mediators of Inflammation
Volume 2010, Article ID 847632, 7 pages
Clinical Study

Levels of Salivary IFN-gamma, TNF-Alfa, and TNF Receptor-2 As Prognostic Markers in (Erosive) Oral Lichen Planus

1Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Cairo University, 43 Zahraa Street, Dokki, Giza 12311, Egypt
2Department of Oral Medicine and Periodontology, Faculty of Dental Medicine, Al Azhar University, Cairo, Egypt
3Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Egypt

Received 11 October 2010; Revised 12 December 2010; Accepted 28 December 2010

Academic Editor: Jan van Amsterdam

Copyright © 2010 Noha A. Ghallab et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To explore the feasibility of detecting salivary levels of IFN-γ, TNF-α, and sTNFR-2 from erosive oral lichen planus (ELP) patients for clinical application, 20 ELP patients were enrolled in the study as were 20 age-sex-matched controls. From all subjects, saliva level of the tested biomarkers was determined by ELISA. Salivary profiles were assessed in ELP patients by ELISA after being treated with prednisone. A significantly higher level of IFN-γ ( ), TNF-α ( ), and sTNFR-2 ( ) was detected in ELP patients before treatment than in controls. Following treatment, the salivary levels of IFN-γ ( ), TNF-α ( ), and sTNFR-2 ( ) decreased significantly when compared to their pretreatment levels. This study demonstrated that salivary IFN-γ, TNF-α, and sTNFR-2 can be detectable in ELP patients and decreased significantly after treatment with prednisone, which may reveal the possibility of using these disease-related biomarkers in diagnosis and monitoring.