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Proinflammatory | Principal cells source | Biological activities |
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IL-1 and IL-1 | Macrophages and APC | Costimulation of APC and T cells inflammation and fever, acute phase reaction hematopoiesis. |
IL-2 | Activated Th1 and NK cells | Proliferation of B cells and activated T cells, NK functions. |
IL-6 | Activated Th2 cells, APC, other somatic cells | Acute phase reaction, thrombopoiesis, B cell proliferation, synergistic with IL-1 and TNF on T cells. |
IL-8 | Macrophages, other somatic cells | Chemoattractant for neutrophils and T cells. |
TNF- | Monocytes and macrophages | Wide ranging biological effects on lipid metabolism, coagulation and endothelial function. Induces inflammation and fever acute phase reaction, weight loss and antitumoral effects. |
IFN-γ | Activated Th1 and NK cells | Induces of class I MHC on all somatic cells, induces class II MHC, an APC and somatic cells, activates macrophages, neutrophils, NK cells, promotes cell-mediated immunity antiviral effects. |
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Anti-inflammatory | | |
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IL-4 | Th2 and mast cells | B cell profileration, eosinophil and mast cell growth and function, IgE and class II MHC expression on B cells, inhibition of monokine production. |
IL-10 | Macrophages and lymphocytes | Exerts its anti-inflammatory activity by inhibiting TNF-induced NFkB activation. |
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