Association of Toll-Like Receptor Signaling and  Reactive Oxygen Species: A Potential Therapeutic Target for  Posttrauma Acute Lung Injury

<table>Role of TLRs in mediating inflammation and organ injury.  Infection not only causes PAMPs release, but also causes tissue and cell damage along with subsequent DAMPs release.  Similarly, injury caused by trauma or various other factors not only leads to DAMPs release but also renders the patient more susceptible to infection and therefore PAMPs release.  In turn,  PAMPs and DAMPs act through TLRs to activate the innate immune system, yet they can also contribute to persistent and deleterious systemic inflammation and organ injury, including ALI.</table>

Mediators of Inflammation

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Figure 1

Figure 1: Association of Toll-Like Receptor Signaling and  Reactive Oxygen Species: A Potential Therapeutic Target for  Posttrauma Acute Lung Injury 